112年度「實體講座：Targeting the DNA Damage Response in Myeloid Malignancy: From Genomes to Drugs」
本講座由國立臺灣大學基因體暨精準醫學研究中心主辦、社團法人台灣微生物菌相與精準健康學會協辦，邀請哈佛大學Dr. Peter Miller演講，歡迎對精準醫學有興趣的你加入！
講座摘要：
Dysregulation of the DNA damage response and p53 activation is a central mechanism by which normal and malignant hematopoietic cells survive genotoxic stresses such as chemotherapy and radiation. Our lab studies how PPM1D, a gene that is recurrently activated in clonal hematopoiesis and myeloid neoplasia, regulates normal hematopoietic stem cell function and how PPM1D contributes to the development of therapy resistance in myelodysplastic syndrome and acute myeloid leukemia. Using a combination of human genetics, mouse models, and engineered cell systems, we have found that PPM1D is a central regulator of hematopoietic cell fitness, particularly in the context of genotoxic stress, and is a target in myeloid malignancies. These biological insights have led to a drug discovery effort to target PPM1D and other regulators of the DNA damage response.
講座時間：112年08月25日（五）上午11:00至12:00。
演講人：哈佛大學Dr. Peter Grant Miller（現職：Assistant Professor of Medicine, Harvard Medical School, Massachusetts General Hospital Center for Cancer Research）
參加對象：台大及台大醫院之學生及教職員。（當天請出示有效身分證件供現場工作人員核對）
講座地點：台北市中正區仁愛路一段1號 國立臺灣大學醫學院103講堂。
報名方式：https://forms.gle/ZGkfN59U4iKSru5v5
報名截止日：即日起至112年08月24日（四）中午12點止。（若報名人數已達講堂座位上限，將提早關閉表單）
講座費用：免費，歡迎多多推廣、共襄盛舉。
更多資訊請參考：附件宣傳海報或本學會網站公告
聯絡人：秘書處 游舒婷
電話：(02)2312-3456#88685
E-mail：tambph@gmail.com
