{"id":3570,"date":"2024-09-24T11:30:08","date_gmt":"2024-09-24T03:30:08","guid":{"rendered":"https:\/\/www.bebi.ntu.edu.tw\/?p=3570"},"modified":"2024-09-24T11:30:33","modified_gmt":"2024-09-24T03:30:33","slug":"%e7%94%9f%e9%86%ab%e9%9b%bb%e8%b3%87%e6%89%80%e6%95%99%e5%b8%ab%e7%a0%94%e7%a9%b6%e4%ba%ae%e9%bb%9e-%e3%80%8c%e5%8a%89%e5%ad%90%e6%af%93%e6%95%99%e6%8e%88%e3%80%8d","status":"publish","type":"post","link":"https:\/\/www.bebi.ntu.edu.tw\/?p=3570","title":{"rendered":"\u751f\u91ab\u96fb\u8cc7\u6240\u6559\u5e2b\u7814\u7a76\u4eae\u9ede-\u300c\u5289\u5b50\u6bd3\u6559\u6388\u300d"},"content":{"rendered":"

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\n\u5289\u5b50\u6bd3\u8001\u5e2b\u57282016\u5e74\u66fe\u7d93\u5728BMC Bioinformatics\u4e0a\u767c\u8868\u4e00\u7bc7\u95dc\u65bc\u300c\u5229\u7528\u53c3\u8003\u9ad4\u8207\u914d\u5c0d\u9ad4\u500b\u9ad4\u5316\u5065\u5eb7\u8207\u75be\u75c5\u9810\u6e2c\u300d[1]\uff0c\u8a72\u7bc7\u6bd4\u8f03\u56db\u7a2e\u75c5\u6bd2\uff08H3N2\u3001H1N1\u3001HRV\u3001RSV\uff09\u5206\u5225\u5728\u56db\u7a2e\u72c0\u6cc1\u4e0b\uff08\u6709\u57fa\u6e96\u53c3\u8003\u3001\u7121\u57fa\u6e96\u53c3\u8003\u3001\u9650\u5236\u6a19\u6e96\u9810\u6e2c\u3001\u5dee\u7570\u5316\u9810\u6e2c\uff09\u7684\u932f\u8aa4\u7387\u4ee5\u53ca\u9078\u64c7\u7684\u57fa\u56e0\u6578\u91cf\u3002\u7d93\u7531\u4e0b\u5716\u88682\u4e2d\u53ef\u4ee5\u770b\u5230\uff0c\u7121\u8ad6\u662f\u54ea\u7a2e\u75c5\u6bd2\uff0c\u5728\u6709\u57fa\u6e96\u53c3\u8003\u7684\u60c5\u6cc1\u4e0b\u5176\u932f\u8aa4\u7387\u4ee5\u53ca\u6240\u9700\u8981\u9078\u64c7\u7684\u57fa\u56e0\u6578\u90fd\u8f03\u5176\u4ed6\u4e09\u7a2e\u72c0\u6cc1\u4f4e\u3002\u540c\u6642\uff0c\u5728\u57168\u4e2d\u53ef\u4ee5\u770b\u5230\u5728\u6709\u53c3\u8003\u7684\u60c5\u6cc1\u4e0b\uff0c\u5176\u56db\u7a2e\u75c5\u6bd2\u4ea4\u96c6\u51fa\u4f86\u7684\u5171\u540c\u57fa\u56e0\u76f8\u8f03\u6c92\u6709\u53c3\u8003\uff08\u57168\u5de6\uff09\u66f4\u70ba\u6e96\u78ba\u3001\u8f03\u5c11\u3002
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\nIn 2002, a severe outbreak of Severe Acute Respiratory Syndrome (SARS) occurred, and in November 2019, the first known case of a novel coronavirus pneumonia epidemic happened in Wuhan, China. The first case of COVID-19 in Taiwan was reported on January 21, 2020, which significantly altered the public’s lifestyle.
\nProfessor Tzu-Yu Liu published a paper in BMC Bioinformatics in 2016, titled \u201cAn individualized predictor of health and disease using paired reference and target samples.\u201d[1] This study compared the error rates and the number of selected genes for four viruses (H3N2, H1N1, HRV, RSV) under four scenarios (with reference, without reference, restricted standard prediction, and differentiated prediction). As shown in Table 2 below, for all virus types, the error rates and the number of selected genes were lower when there\u2019s a baseline reference compared to the other three conditions. Additionally, Figure 8 illustrates that the common genes identified among the four viruses were more accurate and fewer when references were used compared to when there were none (left side of Figure 8).
\nIn conclusion, this study indicates that utilizing reference individuals significantly enhances the accuracy of viral gene interpretation, and this framework holds potential for application in medical diagnostics, drug development, and biology in the future, allowing for greater accuracy.<\/p>\n

\"\"<\/p>\n

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