{"id":3091,"date":"2024-05-07T11:43:03","date_gmt":"2024-05-07T03:43:03","guid":{"rendered":"https:\/\/www.bebi.ntu.edu.tw\/?p=3091"},"modified":"2024-05-07T11:43:03","modified_gmt":"2024-05-07T03:43:03","slug":"%e7%94%9f%e9%86%ab%e9%9b%bb%e8%b3%87%e6%89%80%e6%95%99%e5%b8%ab%e7%a0%94%e7%a9%b6%e4%ba%ae%e9%bb%9e-113%e5%b9%b404%e6%9c%88%e4%bb%bd%e3%80%8c%e5%8a%89%e6%b5%a9%e6%be%a7%e6%95%99%e6%8e%88%e3%80%8d","status":"publish","type":"post","link":"https:\/\/www.bebi.ntu.edu.tw\/?p=3091","title":{"rendered":"\u751f\u91ab\u96fb\u8cc7\u6240\u6559\u5e2b\u7814\u7a76\u4eae\u9ede-113\u5e7404\u6708\u4efd\u300c\u5289\u6d69\u6fa7\u6559\u6388\u300d"},"content":{"rendered":"<h2><strong>\u7814\u7a76\u4e3b\u984c\uff1a\u4f4e\u80fd\u91cf\u8d85\u97f3\u6ce2\u9020\u6210\u5927\u9f20\u52d5\u4f5c\u8166\u5340\u795e\u7d93\u7d30\u80de\u8abf\u7bc0\u6d3b\u52d5\u4e4b\u53ef\u884c\u6027\u8a55\u4f30<\/strong><\/h2>\n<p>\u64b0\u5beb\uff1a\u5b78\u751f\u90b1\u5343\u5bb9<\/p>\n<p>\u4eba\u8033\u80fd\u807d\u5230\u7684\u8072\u97f3\u5927\u7d04\u4ecb\u572820~20000 Hz\u4e4b\u9593\uff0c\u800c\u9ad8\u65bc\u6b64\u983b\u7387\u7bc4\u570d\u4fbf\u7a31\u70ba\u8d85\u97f3\u6ce2\u3002\u8d85\u97f3\u6ce2\u662f\u900f\u904e\u5728\u4e0d\u540c\u4ecb\u8cea\uff08\u7d44\u7e54\uff09\u9593\u7684\u50b3\u905e\u901f\u7387\u4ee5\u5f62\u6210\u5f71\u50cf\uff0c\u5176\u512a\u9ede\u70ba\u5feb\u901f\u4e14\u65b9\u4fbf\u7684\u4f7f\u7528\u65b9\u5f0f\u4ee5\u53ca\u50f9\u683c\u76f8\u8f03\u5176\u4ed6\u6aa2\u9a57\u5de5\u5177\u8f03\u4f4e\u5ec9\uff0c\u4e5f\u56e0\u6b64\u8d85\u97f3\u6ce2\u5e38\u505a\u70ba\u6700\u5e38\u88ab\u4f7f\u7528\u4e26\u61c9\u7528\u7684\u91ab\u5b78\u5f71\u50cf\u5de5\u5177\u4e4b\u4e00\u3002\u6cbb\u7642\u4e0a\u5e38\u4f7f\u7528\u983b\u7387\u8f03\u4f4e\u7684\u8d85\u97f3\u6ce2\u800c\u8f03\u9ad8\u983b\u7387\u7684\u8d85\u97f3\u6ce2\u5247\u5e38\u4f7f\u7528\u65bc\u91ab\u5b78\u8a3a\u65b7\u3002\u5728\u975e\u4fb5\u5165\u6027\u795e\u7d93\u8abf\u8b8a\u7814\u7a76\u65b9\u9762\uff0c\u76f8\u8f03\u65bc\u9871\u5916\u78c1\u523a\u6fc0\u8853(repetitive transcranial magnetic stimulation, rTMS)\u548c\u8de8\u9871\u76f4\u6d41\u96fb\u523a\u6fc0(transcranial direct current stimulation, tDCS)\u53ea\u80fd\u5728\u76f8\u5c0d\u6dfa\u5c64\u3001\u7121\u6cd5\u7a7f\u900f\u6df1\u5c64\u8166\u5340\u4e14\u5177\u6709\u500b\u9ad4\u5dee\u7570\u5316\uff0c\u65b0\u7a4e\u7684\u7d93\u9871\u805a\u7126\u5f0f\u8d85\u97f3\u6ce2(Transcranial focused ultrasound, tFUS)\u6280\u8853\u5229\u7528\u66f2\u9762\u578b\u58d3\u96fb\u9676\u74f7\u4f7f\u6ce2\u805a\u7126\u5728\u540c\u4e00\u9ede\uff0c\u5177\u6709\u8f03\u9ad8\u7684\u7a7a\u9593\u89e3\u6790\u5ea6\u4e26\u53ef\u4ee5\u66f4\u6709\u6548\u7684\u5230\u9054\u4eba\u9ad4\u8166\u90e8\u6df1\u8655\uff0c\u4e14\u6839\u64da\u904e\u5f80\u7814\u7a76\u986f\u793atFUS\u7684\u80fd\u91cf\u662f\u6291\u5236\u795e\u7d93\u8abf\u8b8a\u7684\u91cd\u8981\u53c3\u6578\u4e4b\u4e00\u3002<\/p>\n<p>\u6709\u5225\u65bc\u904e\u5f80\u7814\u7a76\u767c\u8868\u5728\u6d3b\u9ad4\u5916\u4f7f\u7528\u4f4e\u80fd\u91cf\u8d85\u97f3\u6ce2\u8a98\u5c0e\u795e\u7d93\u8abf\u8b8a\u4e4b\u5f71\u97ff\uff0c\u5289\u6d69\u6fa7\u6559\u6388\u53ca\u5176\u5718\u968a\u5728\u5927\u9f20\u4e2d\u4f7f\u7528\u4e0d\u540c\u91cf\u503c\u7684\u4f4e\u80fd\u91cf\u8d85\u97f3\u6ce2\u89c0\u6e2c\u523a\u6fc0\u5f8c\u4e00\u6bb5\u6642\u9593\u5167\u5176\u904b\u52d5\u795e\u7d93\u96fb\u4f4d(motor-evoked potentials, MEPs)\u4e4b\u8b8a\u5316[1]\uff0c\u4e26\u85c9\u6b64\u5b9a\u7fa9\u51fa\u80fd\u6709\u6548\u4f7f\u7528tFUS\u523a\u6fc0\u5927\u9f20\u904b\u52d5\u8166\u5340\u8a98\u5c0e\u795e\u7d93\u8abf\u8b8a\u5f71\u97ff\u4e4b\u6700\u4f4e\u503c(\u7d040.338 mW\/cm<sup>2<\/sup>)\u3002\u6839\u64da\u7d50\u679c\u986f\u793a\uff0c\u7d93\u904e5\u5206\u9418\u7684tFUS\u523a\u6fc0\u5f8c\uff0c\u53ef\u4ee5\u964d\u4f4e\u904b\u52d5\u795e\u7d93\u6d3b\u52d5\u7d0430\u5206\u9418\uff0c\u4e26\u4e14\u589e\u9032GABAergic\u795e\u7d93\u7684\u6291\u5236\u6027\u3002\u8a72\u7814\u7a76\u4e5f\u6307\u51fa\u5728tFUS\u6291\u5236\u795e\u7d93\u8abf\u8b8a\u4e2d\uff0c\u6291\u5236\u6027\u795e\u7d93\u5143\u7684\u6d3b\u6027\u662f\u975e\u5e38\u91cd\u8981\u7684\u6307\u6a19\u4e4b\u4e00\u3002<\/p>\n<p>\u96d6\u7136\u5c1a\u672a\u6709\u7814\u7a76\u986f\u793a\u5728\u8f03\u9577\u6642\u9593\u4e0btFUS\u5c0d\u904b\u52d5\u795e\u7d93\u5143\u6d3b\u6027\u548c\u8868\u73fe\u7684\u5f71\u97ff\u4ee5\u53ca\u5176\u5728\u4eba\u9ad4\u4e0a\u7684\u61c9\u7528\uff1b\u4f46\u5728\u672a\u4f86\uff0ctFUS\u5177\u6709\u9ad8\u5ea6\u767c\u5c55\u6027\u4ee5\u53ca\u61c9\u7528\u6027\uff0c\u4e0d\u4f46\u6709\u6a5f\u6703\u4f5c\u70ba\u8a3a\u65b7\u5f71\u50cf\u5de5\u5177\uff0c\u9084\u6709\u53ef\u80fd\u4f5c\u70ba\u6cbb\u7642\u795e\u7d93\u7cfb\u7d71\u6027\u75be\u75c5\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Humans can hear sound with frequencies between 20 and 20,000 Hz, and the sound wave frequency that is above this interval is called ultrasound. The relatively low cost and rapid and convenient use of ultrasound make it one of the most commonly used and applied medical imaging tools. The lower-frequency ultrasound is often used in therapy, while higher-frequency is commonly used in medical diagnosis. Compared to techniques such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) in non-invasive neuromodulation research, which are limited to relatively superficial layers and cannot penetrate deeper than the cortical layer of the brain and exhibit both within and between individuals, Transcranial Focused Ultrasound (tFUS) offers higher spatial resolution and can more effectively reach deep brain areas. Previous studies have shown that the intensity of tFUS is one of the important parameters for inhibiting neuromodulation.<\/p>\n<p>&nbsp;<\/p>\n<p>In contrast to previous studies conducted in vitro using low-energy ultrasound to induce neuromodulation effects, Professor Hao-Li Liu and his team observed changes in motor-evoked potentials (MEPs) in rats after stimulation with different intensities of low-energy ultrasound over a period of time.[1] They defined the value (approximately 0.338 mW\/cm<sup>2<\/sup>) as a threshold that can effectively induce neuromodulation effects in the motor cortex of rats using tFUS stimulation. According to the results, after 5 minutes of tFUS stimulation, motor neuron activity could be suppressed for about 30 minutes and it can also enhancing the inhibitory of GABAergic neurons. The study also indicated that the activity of inhibitory neurons is a crucial indicator in tFUS-induced neuromodulation.<\/p>\n<p>&nbsp;<\/p>\n<p>Although no studies are showing the long-term effects of tFUS on motor neuron activity and the weak ultrasound\u2019s application in humans, tFUS has high potential for development and application in the future. It may not only serve as a diagnostic imaging tool but also potentially be used in the treatment of neuropsychiatric disorders.<\/p>\n<p>&nbsp;<\/p>\n<p>\u53c3\u8003\u6587\u737b<\/p>\n<ol>\n<li>Chu, P.-C., et al., <em>Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex.<\/em> International Journal of Molecular Sciences, 2023. <strong>24<\/strong>(3): p. 2578.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u4e3b\u984c\uff1a\u4f4e\u80fd\u91cf\u8d85\u97f3\u6ce2\u9020\u6210\u5927\u9f20\u52d5\u4f5c\u8166\u5340\u795e\u7d93\u7d30\u80de\u8abf\u7bc0\u6d3b\u52d5\u4e4b\u53ef\u884c\u6027\u8a55\u4f30 \u64b0\u5beb\uff1a\u5b78\u751f\u90b1\u5343\u5bb9 \u4eba\u8033\u80fd\u807d\u5230\u7684\u8072\u97f3\u5927\u7d04\u4ecb\u5728 [&#8230;]\n","protected":false},"author":2,"featured_media":3092,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-award"],"jetpack_featured_media_url":"https:\/\/www.bebi.ntu.edu.tw\/wp-content\/uploads\/2024\/05\/\u6559\u5e2b\u7814\u7a76\u4eae\u9ede-\u5289\u6d69\u6fa7.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/3091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3091"}],"version-history":[{"count":1,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/3091\/revisions"}],"predecessor-version":[{"id":3093,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/3091\/revisions\/3093"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/3092"}],"wp:attachment":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}