{"id":2558,"date":"2023-07-11T15:05:06","date_gmt":"2023-07-11T07:05:06","guid":{"rendered":"https:\/\/www.bebi.ntu.edu.tw\/?p=2558"},"modified":"2025-09-03T15:51:12","modified_gmt":"2025-09-03T07:51:12","slug":"%e3%80%90%e8%ac%9b%e5%ba%a7%e5%85%ac%e5%91%8a%e3%80%91112%e5%b9%b4%e5%ba%a6%e3%80%8c%e5%af%a6%e9%ab%94%e8%ac%9b%e5%ba%a7%ef%bc%9atargeting-the-dna-damage-response-in-myeloid-malignancy-from-genomes-t","status":"publish","type":"post","link":"https:\/\/www.bebi.ntu.edu.tw\/?p=2558","title":{"rendered":"\u3010\u8b1b\u5ea7\u516c\u544a\u3011112\u5e74\u5ea6\u300c\u5be6\u9ad4\u8b1b\u5ea7\uff1aTargeting the DNA Damage Response in Myeloid Malignancy: From Genomes to Drugs\u300d\u5831\u540d\u958b\u8dd1\u5566\uff01"},"content":{"rendered":"

112\u5e74\u5ea6\u300c\u5be6\u9ad4\u8b1b\u5ea7\uff1aTargeting the DNA Damage Response in Myeloid Malignancy: From Genomes to Drugs\u300d<\/u><\/strong><\/p>\n

\u672c\u8b1b\u5ea7\u7531\u570b\u7acb\u81fa\u7063\u5927\u5b78\u57fa\u56e0\u9ad4\u66a8\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u4e2d\u5fc3\u4e3b\u8fa6\u3001\u793e\u5718\u6cd5\u4eba\u53f0\u7063\u5fae\u751f\u7269\u83cc\u76f8\u8207\u7cbe\u6e96\u5065\u5eb7\u5b78\u6703\u5354\u8fa6\uff0c\u9080\u8acb\u54c8\u4f5b\u5927\u5b78Dr. Peter Miller\u6f14\u8b1b\uff0c\u6b61\u8fce\u5c0d\u7cbe\u6e96\u91ab\u5b78\u6709\u8208\u8da3\u7684\u4f60\u52a0\u5165\uff01<\/p>\n

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Dysregulation of the DNA damage response and p53 activation is a central mechanism by which normal and malignant hematopoietic cells survive genotoxic stresses such as chemotherapy and radiation.\u00a0 Our lab studies how PPM1D<\/em>, a gene that is recurrently activated in clonal hematopoiesis and myeloid neoplasia, regulates normal hematopoietic stem cell function and how PPM1D<\/em> contributes to the development of therapy resistance in myelodysplastic syndrome and acute myeloid leukemia.\u00a0 Using a combination of human genetics, mouse models, and engineered cell systems, we have found that PPM1D<\/em> is a central regulator of hematopoietic cell fitness, particularly in the context of genotoxic stress, and is a target in myeloid malignancies.\u00a0 These biological insights have led to a drug discovery effort to target PPM1D<\/em> and other regulators of the DNA damage response.<\/p>\n

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\n\u6f14\u8b1b\u4eba\uff1a\u54c8\u4f5b\u5927\u5b78Dr. Peter Grant Miller<\/strong>\uff08\u73fe\u8077\uff1aAssistant Professor of Medicine, Harvard Medical School, Massachusetts General Hospital Center for Cancer Research\uff09
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\n\u5831\u540d\u65b9\u5f0f\uff1ahttps:\/\/forms.gle\/ZGkfN59U4iKSru5v5<\/a>
\n\u5831\u540d\u622a\u6b62\u65e5\uff1a\u5373\u65e5\u8d77\u81f3112\u5e7408\u670824\u65e5\uff08\u56db\uff09\u4e2d\u534812\u9ede\u6b62<\/u><\/strong>\u3002\uff08\u82e5\u5831\u540d\u4eba\u6578\u5df2\u9054\u8b1b\u5802\u5ea7\u4f4d\u4e0a\u9650\uff0c\u5c07\u63d0\u65e9\u95dc\u9589\u8868\u55ae\uff09
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\n\u96fb\u8a71\uff1a(02)2312-3456#88685
\nE-mail\uff1atambph@gmail.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

112\u5e74\u5ea6\u300c\u5be6\u9ad4\u8b1b\u5ea7\uff1aTargeting the DNA Damage Response in Myeloid […]\n","protected":false},"author":2,"featured_media":2560,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2558","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-speech"],"jetpack_featured_media_url":"https:\/\/www.bebi.ntu.edu.tw\/wp-content\/uploads\/2023\/07\/Banner-Bioinfo-v2-scaled.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/2558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2558"}],"version-history":[{"count":1,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/2558\/revisions"}],"predecessor-version":[{"id":2561,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/2558\/revisions\/2561"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/2560"}],"wp:attachment":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}