{"id":2178,"date":"2022-10-18T12:25:23","date_gmt":"2022-10-18T04:25:23","guid":{"rendered":"https:\/\/www.bebi.ntu.edu.tw\/?p=2178"},"modified":"2022-10-18T12:25:23","modified_gmt":"2022-10-18T04:25:23","slug":"highlights-of-the-research-by-the-professor-of-biomedical-electronics-and-bioinformatics-institute-202210-professor-fuh-chiou-shann","status":"publish","type":"post","link":"https:\/\/www.bebi.ntu.edu.tw\/?p=2178&lang=en","title":{"rendered":"Highlights of the research by the professor of Biomedical Electronics and Bioinformatics Institute. -202210 Professor Fuh, Chiou-Shann"},"content":{"rendered":"
\n
An Outperforming Artificial Intelligence Model to Identify Referable Blepharoptosis for General Practitioners<\/div>\n
<\/div>\n<\/div>\n
\n
Blepharoptosis, also known as ptosis, is the drooping or inferior displacement of the upper eyelid. Ptosis can obstruct the visual axis and affect vision. It can be a presenting sign of a severe medical disorder, such as ocular myasthenia [1], third cranial nerve palsy [2], or Horner syndrome [3]. It is essential for general practitioners to accurately diagnose ptosis to assist in decision-making for referral and work up when necessary.<\/div>\n<\/div>\n
\n
With low repeatability and reproducibility in measuring eyelid landmarks and the effect of learning curves [5,6], accurately recognizing ptosis is challenging for non-ophthalmologists. As a result, Professor Chiou-Shann Fuh and his team developed an artificial intelligence model that automatically identifies referable blepharoptosis as an automated tool to assist general practitioners in diagnosing ptosis.<\/div>\n<\/div>\n
\n
In this study, Fuh\u2019s team used VGG-16 as the base structure to train an AI model whose training purpose is to diagnose ptosis accurately. The last few layers of VGG-160s architecture were replaced with a global max pooling layer followed by fully connected layers and a sigmoid function for the binary classification problem. This model also performs transfer learning by importing weights trained on ImageNet and applying data augmentation to prevent overfitting. On the other hand, three specialists, one in emergency medicine, neurology, and one in family medicine, were tested on behalf of the non-ophthalmologist group. For the AI model and physician group, this study provided the same test set for both sides, including 25 healthy eyelids and 25 ptotic eyelids, to distinguish ptotic eyelids from healthy eyelids. The test showed that the accuracy of the AI model was 90%, with a sensitivity of 92% and a specificity of 88%; the accuracy of the physician group model was 77.33%, with a sensitivity of 72% and a specificity of 82.67%. These results suggest that an AI-aided diagnostic tool can accurately detect blepharoptosis and prompt referral for ophthalmic evaluation when necessary.<\/div>\n<\/div>\n
\n
In addition, to visualize reasonable AI predictions, Grad-CAM also helped identify image dataset biases. For example, a preoperative marking around the eye or a postoperative suture on the eyelid may provide misleading clues to the AI model rather than eyelid information for blepharoptosis. The results of Grad-CAM (as shown in the attached figure) demonstrated a hotspot area (0.5\u20131.0 in weights) between the upper eyelid margin and central corneal light reflex, which is clinically compatible with the MRD- 1 concept. The background cold zone (0\u20130.2 in weights) successfully excluded dataset biases, providing more vital faithfulness. With more extensive and diverse data utilization in the future, more precise results can be expected to understand AI predictions.<\/div>\n<\/div>\n
<\/div>\n
\n

\u7814\u7a76\u4e3b\u984c\uff1a\u5354\u52a9\u5168\u79d1\u91ab\u5e2b\u8b58\u5225\u8f49\u8a3a\u4e0a\u77bc\u4e0b\u5782\u7684\u5353\u8d8a\u4eba\u5de5\u667a\u80fd\u6a21\u578b
\n\u64b0\u5beb\uff1a\u5b78\u751f\u738b\u99a8<\/p>\n

\u4e0a\u77bc\u4e0b\u5782\uff0c\u6307\u4e0a\u773c\u77bc\u4e0b\u5782\u6216\u4e0b\u79fb\u3002\u6b64\u75c7\u72c0\u6703\u963b\u7919\u8996\u8ef8\u4e26\u5f71\u97ff\u8996\u529b\uff0c\u4e14\u53ef\u80fd\u70ba\u56b4\u91cd\u91ab\u5b78\u75be\u75c5\u7684\u5148\u5146\uff0c\u4f8b\u5982\u773c\u808c\u7121\u529b\u3001\u7b2c\u4e09\u9871\u795e\u7d93\u9ebb\u75fa\u6216\u970d\u7d0d\u7d9c\u5408\u5fb5\u7b49\u3002\u5c0d\u65bc\u5168\u79d1\u91ab\u751f\u4f86\u8aaa\uff0c\u70ba\u4e86\u505a\u51fa\u8f49\u8a3a\u6c7a\u7b56\u4e26\u5728\u5fc5\u8981\u6642\u9032\u884c\u6aa2\u67e5\uff0c\u6e96\u78ba\u8a3a\u65b7\u4e0a\u77bc\u4e0b\u5782\u975e\u5e38\u91cd\u8981\u3002\u800c\u5c0d\u975e\u773c\u79d1\u91ab\u751f\u800c\u8a00\uff0c\u7531\u65bc\u6e2c\u91cf\u773c\u77bc\u6a19\u8a8c\u7684\u91cd\u8907\u6027\u548c\u518d\u73fe\u6027\u4f4e\u4ee5\u53ca\u5b78\u7fd2\u66f2\u7dda\u7684\u5f71\u97ff\uff0c\u6e96\u78ba\u8b58\u5225\u4e0a\u77bc\u4e0b\u5782\u76f8\u7576\u5177\u6709\u6311\u6230\u6027\u3002\u7531\u6b64\uff0c\u5085\u6978\u5584\u6559\u6388\u53ca\u5176\u5718\u968a\u958b\u767c\u4e86\u4e00\u7a2e\u80fd\u5920\u81ea\u52d5\u6e96\u78ba\u8b58\u5225\u53ef\u53c3\u8003\u4e0a\u77bc\u4e0b\u5782\u7684\u4eba\u5de5\u667a\u80fd\u6a21\u578b\uff0c\u4f5c\u70ba\u5354\u52a9\u5168\u79d1\u91ab\u751f\u8a3a\u65b7\u4e0a\u77bc\u4e0b\u5782\u7684\u81ea\u52d5\u5316\u5de5\u5177\u3002<\/p>\n

\u5728\u9019\u9805\u7814\u7a76\u4e2d\uff0c\u5085\u6559\u6388\u5718\u968a\u4f7f\u7528VGG-16\u4f5c\u70ba\u57fa\u790e\u7d50\u69cb\u4f86\u8a13\u7df4AI\u6a21\u578b\uff0c\u5176\u76ee\u7684\u70ba\u6e96\u78ba\u8a3a\u65b7\u4e0a\u77bc\u4e0b\u5782\u3002VGG-160s\u67b6\u69cb\u7684\u6700\u5f8c\u6578\u5c64\u88ab\u66ff\u63db\u70ba\u5168\u5c40\u6700\u5927\u6c60\u5316\u5c64\uff0c\u7136\u5f8c\u662f\u5168\u9023\u63a5\u5c64\u548c\u7528\u65bc\u4e8c\u5143\u5206\u985e\u554f\u984c\u7684sigmoid\u51fd\u6578\u3002\u672c\u6a21\u578b\u4ea6\u901a\u904e\u5c0e\u5165\u5728ImageNet\u4e0a\u8a13\u7df4\u7684\u6b0a\u91cd\u4f86\u57f7\u884c\u9077\u79fb\u5b78\u7fd2\uff0c\u4e26\u61c9\u7528\u6578\u64da\u589e\u5f37\u4ee5\u9632\u6b62\u904e\u5ea6\u64ec\u5408\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6025\u8a3a\u91ab\u5b78\u3001\u795e\u7d93\u5167\u79d1\u548c\u5bb6\u5ead\u91ab\u5b78\u5404\u4e00\u540d\u7684\u4e09\u540d\u5c08\u5bb6\u5247\u4ee3\u8868\u975e\u773c\u79d1\u91ab\u5e2b\u7d44\u63a5\u53d7\u6e2c\u8a66\u3002\u5c0d\u65bcAI\u6a21\u578b\u548c\u91ab\u5e2b\u7d44\uff0c\u672c\u7814\u7a76\u63d0\u4f9b\u4e86\u96d9\u65b9\u76f8\u540c\u7684\u6e2c\u8a66\u96c6\uff0c\u5305\u62ec25\u500b\u5065\u5eb7\u773c\u77bc\u548c25\u500b\u4e0b\u5782\u773c\u77bc\uff0c\u4ee5\u5340\u5206\u4e0b\u5782\u773c\u77bc\u548c\u5065\u5eb7\u773c\u77bc\u3002\u8a72\u6e2c\u8a66\u986f\u793a\uff0cAI\u6a21\u578b\u7684\u6e96\u78ba\u7387\u70ba90%\uff0c\u9748\u654f\u5ea6\u70ba92%\uff0c\u7279\u7570\u6027\u70ba88%\uff1b\u800c\u91ab\u5e2b\u7d44\u7684\u6e96\u78ba\u7387\u70ba77.33%\uff0c\u9748\u654f\u5ea6\u70ba72%\uff0c\u7279\u7570\u6027\u70ba82.67%\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0c\u4eba\u5de5\u667a\u80fd\u8f14\u52a9\u8a3a\u65b7\u5de5\u5177\u53ef\u4ee5\u6e96\u78ba\u6aa2\u6e2c\u4e0a\u77bc\u4e0b\u5782\uff0c\u4e26\u5728\u5fc5\u8981\u6642\u53ca\u6642\u8f49\u8a3a\u9032\u884c\u773c\u79d1\u8a55\u4f30\u3002<\/p>\n

\u6b64\u5916\uff0c\u70ba\u4e86\u53ef\u8996\u5316\u5408\u7406\u7684AI\u9810\u6e2c\uff0cGrad-CAM\u9084\u6709\u52a9\u65bc\u8b58\u5225\u5716\u50cf\u4e2d\u7684\u6578\u64da\u96c6\u504f\u5dee\u3002\u4f8b\u5982\uff0c\u773c\u90e8\u5468\u570d\u7684\u8853\u524d\u6a19\u8a18\u6216\u773c\u77bc\u8853\u5f8c\u7e2b\u5408\u53ef\u80fd\u6703\u70baAI\u6a21\u578b\u63d0\u4f9b\u8aa4\u5c0e\u6027\u7dda\u7d22\uff0c\u800c\u4e0d\u662f\u773c\u77bc\u4e0b\u5782\u7684\u773c\u77bc\u4fe1\u606f\u3002Grad-CAM \u7684\u7d50\u679c\uff08\u5982\u9644\u5716\uff09\u986f\u793a\u4e86\u4e0a\u773c\u77bc\u908a\u7de3\u548c\u4e2d\u592e\u89d2\u819c\u5149\u53cd\u5c04\u4e4b\u9593\u7684\u71b1\u9ede\u5340\u57df\uff08\u91cd\u91cf\u70ba 0.5-1.0\uff09\uff0c\u9019\u5728\u81e8\u5e8a\u4e0a\u8207 MRD-1 \u6982\u5ff5\u517c\u5bb9\u3002\u80cc\u666f\u4e2d\u7684\u51b7\u5340\uff08\u6b0a\u91cd\u70ba 0-0.2\uff09\u6210\u529f\u6392\u9664\u4e86\u6578\u64da\u96c6\u504f\u5dee\uff0c\u63d0\u4f9b\u4e86\u66f4\u5f37\u7684\u5fe0\u5be6\u5ea6\u3002\u96a8\u8457\u672a\u4f86\u6578\u64da\u4f7f\u7528\u91cf\u7684\u589e\u52a0\u548c\u591a\u6a23\u5316\uff0c\u53ef\u4ee5\u671f\u5f85\u66f4\u7cbe\u78ba\u7684\u7d50\u679c\u4f86\u7406\u89e3\u4eba\u5de5\u667a\u80fd\u7684\u9810\u6e2c\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

An Outperforming Artificial Intelligence Model to Ident […]\n","protected":false},"author":2,"featured_media":2177,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[68],"tags":[],"class_list":["post-2178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-en"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/www.bebi.ntu.edu.tw\/wp-content\/uploads\/2022\/10\/figure.png","_links":{"self":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/2178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2178"}],"version-history":[{"count":1,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/2178\/revisions"}],"predecessor-version":[{"id":2179,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/2178\/revisions\/2179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/2177"}],"wp:attachment":[{"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bebi.ntu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}