Schizophrenia is a brain disorder that involves a disturbance of thinking and perception. In the total global burden of disease, such mental illness accounts for over 13%, which is even higher than vascular diseases and cancer, ranking first in the global disease burden. According to statistics from the Health Insurance Administration, Ministry of Health and Welfare in 2019, the number of patients with schizophrenia in Taiwan was as high as 106,000, and the average cost of medical treatment per person was as high as 108,500 NT dollars, causing heavy pressure and financial burdens on patients’ families.<\/p>\n
Patients with schizophrenia generally have positive, negative, and cognitive symptoms. Nowadays, positive symptoms can already be treated with corresponding available drugs. However, negative and cognitive symptoms have yet to be properly treated. After years of research, Professor Zeng Yufeng and her team found that in the brain of schizophrenia patients, the activity of D-amino acid oxidase (DAO) significantly increases, making the function of N-methyl-D-aspartate (NMDA) receptor low. As a result, Professor Zeng led the team to use artificial intelligence to simulate the structure of NMDA receptors. Moreover, the team used big data and machine learning to search and compare street drugs, improve the shortcomings of traditional drugs, and develop a series of DAO inhibitors (DAOIs) small molecule compounds. Among them, the drug numbered RS-D7 can effectively enhance the function of NMDA receptors and improve animal behavior patterns in both cell tests and animal tests. In a clinical trial of 24 patients with schizophrenia, the symptoms of the patients were significantly improved within four weeks, confirming that the drug could alleviate the negative and cognitive symptoms of the patients by 100%.<\/p>\n
The clinical usage of RS-D7 is safe. It is a small molecule compound that can be constantly used alone or in combination with other psychiatric drugs. If the new drug developed can be launched as scheduled in the future, it will benefit many patients suffering from schizophrenia and their families, improve the quality and efficacy of mental illness medical care, and reduce huge social costs.<\/p>\n
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\n\u64b0\u5beb\uff1a\u5b78\u751f \u738b\u99a8<\/p>\n
\u601d\u89ba\u5931\u8abf\u75c7 (schizophrenia)\uff0c\u5373\u793e\u6703\u4e0a\u4fd7\u7a31\u7684\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u662f\u4e00\u7a2e\u601d\u8003\u53ca\u77e5\u89ba\u5931\u8abf\u7684\u8166\u90e8\u75be\u75c5\u3002\u5728\u5168\u7403\u75be\u75c5\u7e3d\u8ca0\u64d4\u4e2d\uff0c\u6b64\u985e\u7cbe\u795e\u75be\u75c5\u4f54\u4e86\u8db3\u8db313%\uff0c\u751a\u81f3\u9ad8\u65bc\u8840\u7ba1\u75be\u75c5\u53ca\u764c\u75c7\uff0c\u662f\u5168\u7403\u75be\u75c5\u8ca0\u64d4\u4e4b\u9996\u3002\u6839\u64da\u885b\u798f\u90e8\u5065\u4fdd\u7f72\u57282019\u5e74\u7684\u7d71\u8a08\uff0c\u570b\u5167\u601d\u89ba\u5931\u8abf\u75c7\u60a3\u8005\u5c31\u91ab\u4eba\u6578\u9ad8\u905410.6\u842c\u4eba\uff0c\u6bcf\u4eba\u5e73\u5747\u5c31\u91ab\u8cbb\u7528\u66f4\u9ad8\u905410.85\u842c\u5143\uff0c\u5c0d\u60a3\u8005\u5bb6\u5c6c\u9020\u6210\u6c89\u91cd\u7684\u58d3\u529b\u8207\u7d93\u6fdf\u8ca0\u64d4\u3002<\/p>\n
\u601d\u89ba\u5931\u8abf\u75c7\u60a3\u8005\u666e\u904d\u6703\u51fa\u73fe\u6b63\u6027\u3001\u8ca0\u6027\u8207\u8a8d\u77e5\u529f\u80fd\u5931\u8abf\u7b49\u75c7\u72c0\uff0c\u5176\u4e2d\u6b63\u6027\u75c7\u72c0\u5df2\u6709\u5c0d\u61c9\u7684\u5e02\u552e\u85e5\u7269\u80fd\u52a0\u4ee5\u6cbb\u7642\u3002\u7136\u800c\uff0c\u8ca0\u6027\u75c7\u72c0\u548c\u8a8d\u77e5\u529f\u80fd\u5931\u8abf\u81f3\u4eca\u537b\u4ecd\u6c92\u6709\u5408\u9069\u7684\u6cbb\u7642\u85e5\u7269\u3002\u901a\u904e\u591a\u5e74\u7684\u7814\u7a76\uff0c\u66fe\u5b87\u9cf3\u6559\u6388\u53ca\u5176\u5718\u968a\u767c\u73fe\u5728\u601d\u89ba\u5931\u8abf\u75c7\u60a3\u8005\u7684\u8166\u90e8\u4e2d\uff0c\u5176\u80fa\u57fa\u9178\u6c27\u5316\u9176 (DAO) \u7684\u8868\u73fe\u91cf\u53ca\u6d3b\u6027\u6703\u660e\u986f\u589e\u52a0\uff0c\u4f7f\u5f97N-\u7532\u57fa-D-\u5929\u51ac\u80fa\u9178 (NMDA) \u7684\u53d7\u9ad4\u529f\u80fd\u4f4e\u4e0b\u3002\u56e0\u6b64\uff0c\u66fe\u6559\u6388\u5e36\u9818\u5718\u968a\uff0c\u4f7f\u7528AI\u6280\u8853\u6a21\u64ecNMDA\u53d7\u9ad4\u7d50\u69cb\uff0c\u518d\u4ee5AI\u5927\u6578\u64da\u8207\u6a5f\u5668\u5b78\u7fd2\u7684\u65b9\u5f0f\u641c\u5c0b\u6bd4\u5c0d\u5e02\u552e\u85e5\u7269\uff0c\u6539\u826f\u50b3\u7d71\u85e5\u7269\u7684\u7f3a\u9ede\uff0c\u958b\u767c\u4e26\u5408\u6210\u4e00\u7cfb\u5217\u7684DAO\u6291\u5236\u5291 (DAOIs) \u5c0f\u5206\u5b50\u5316\u5408\u7269\u3002\u5728\u6b64\u4e4b\u4e2d\uff0c\u7de8\u865fRS-D7\u7684\u85e5\u7269\u5728\u7d30\u80de\u8a66\u9a57\u53ca\u52d5\u7269\u8a66\u9a57\u4e2d\uff0c\u7686\u53ef\u4ee5\u6709\u6548\u63d0\u5347NMDA\u53d7\u9ad4\u529f\u80fd\u4e26\u6539\u5584\u52d5\u7269\u884c\u70ba\u6a21\u5f0f\u3002\u572824\u4f4d\u601d\u89ba\u5931\u8abf\u75c7\u75c5\u60a3\u7684\u7684\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u60a3\u8005\u57284\u9031\u5167\u75c7\u72c0\u986f\u8457\u6539\u5584\uff0c\u8b49\u5be6\u6b64\u85e5\u7269\u80fd100%\u7de9\u89e3\u75c5\u60a3\u7684\u8ca0\u6027\u75c7\u72c0\u8207\u8a8d\u77e5\u529f\u80fd\u5931\u8abf\u3002<\/p>\n
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